Smoking has a number of negative consequences on organs that do not come into direct touch with the smoke, such as the liver. It has three key negative effects on the liver: direct or indirect toxicity, immunological effects, and carcinogenic consequences. Tobacco use produces chemical compounds with cytotoxic potential, which contribute to necroinflammation and fibrosis. Furthermore, smoking promotes the production of pro-inflammatory cytokines (IL-1, IL-6, and TNF-), which are implicated in liver cell damage. It promotes secondary polycythemia and, as a result, increased red cell mass and turnover, which may be a contributing factor to secondary iron overload illness by boosting oxidative stress in hepatocytes. Increased red cell mass and turnover are linked to increased purine catabolism, which promotes excessive uric acid generation. Smoking impairs both cell-mediated and humoral immune responses by inhibiting lymphocyte growth and promoting lymphocyte death. Smoking also raises blood and hepatic iron levels, which causes oxidative stress and lipid peroxidation, which leads to stellate cell activation and the development of fibrosis. Tobacco use produces carcinogenic chemicals that enhance the incidence of hepatocellular carcinoma (HCC) in people with viral hepatitis and are independent of viral infection. Tobacco use has been linked to p53 suppression (tumour suppressor gene). Furthermore, smoking suppresses T-cell responses and is linked to decreased tumour cell surveillance. Furthermore, it has been observed that frequent smoking has an effect on the sustained virological response to interferon (IFN) therapy in hepatitis C patients, which can be improved with recurrent phlebotomy. Smoker's syndrome is a clinicopathological disorder in which patients have periods of facial flushing, palm and sole warmth, throbbing headache, fullness in the head, dizziness, lethargy, prickling feeling, pruritus, and arthralgia.
As a sign of gratitude for how my wife was saved from PCOS & Gastro Disorder, I decided to reach out to those still suffering from this.
ReplyDeleteMy wife suffered pcos in the year 2013 and it was really tough and heartbreaking for me because she was my everything and the symptoms were terrible, she always complained of heavy menstruation, and she always had difficulty falling asleep . We tried various therapies prescribed by our neurologist but none could cure her. I searched for a cure and I saw a testimony by someone who was cured and so many others with similar body problems, and they left the contact of this doctor who has the cure to pcos . I never imagined polycystic ovary syndrome. has a natural cure not until i contacted him and he assured me my wife will be fine. I got the herbal medication he recommended and my wife used it and in one months time she was fully okay even up till this moment she is so full of life. polycystic ovary syndrome. has a cure and he has herbal cure for Herpes,HIV/Aids,Diabetes,Neuro Disease,Cancer,Back Pain,COPD,Parkinson, and other disease you can visit Dr Itua herbal center website to read more www.drituaherbalcenter.com or email drituaherbalcenter@gmail.com on how to get the medication. Thanks admin for such an informative blog.